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In August 1494, King Charles VIII of France led his army of 50,000 soldiers and a large artillery train into northern Italy.
The soldiers were mostly mercenaries – Flemish, Gascon, Swiss, Italian, and Spanish – and were accompanied by 800 camp followers including cooks, medical attendants and prostitutes.
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I In the 1980’s palaeopathological studies found possible evidence that supported this hypothesis and that syphilis was an old treponeal disease which in the late 15th century had suddenly evolved to become different and more virulent.